2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Polo-like Kinase (PLK)
  5. Polo-like Kinase (PLK) Degrader

Polo-like Kinase (PLK) Degrader

Polo-like Kinase (PLK) Isoform Comparison

Polo-like Kinase (PLK) Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-149324
    SP27
    		Degrader 99.21%
    SP27 is a PROTAC that can selective degrades PLK4, with a DC50 of 19.5 nM. SP27 can be used for the research of breast cancer.
  • HY-175000
    L14-8
    		Degrader
    L14-8 is a potent ferroptosis inducer. L14-8 promotes PLK1 degradation via ubiquitination, increasing TP53 phosphorylation to enhance SAT1 transcription, thereby triggering ferroptosis and cancer cell death. L14-8 can be used for the study of advanced prostate cancer.